The charity is keen to focus renewed marketing activity on fundraising.
The organisation had been concentrating on pure brand-building since the merger of the Cancer Research ±±¾©Èü³µpk10 and Imperial Cancer Research in 2001.
Its advertising and direct marketing business, formerly handled by WWAV Rapp Collins, will now be run by Ogilvy & Mather and OgilvyOne respectively.
While the agencies will ensure advertising is aligned with below-the-line work, Ogilvy & Mather is likely to be responsible for creating a clearer brand positioning.
The account was handed to the Ogilvy Group following a pitch against Rainey Kelly Campbell Roalfe/ Y&R and Harrison Troughton Wunderman.
The change of agency follows the charity's £3.2m 'All Clear' campaign by WWAV, which earlier this year achieved a 62% recall among consumers in its first week on TV.