The Oscar-winning actress was signed up as the face of Burberry's new perfume, Burberry London, in January in the group's first global print ad campaign, which was shot by famed photographer Mario Testino.
The move by Burberry, which has often been associated with the "chav" culture in the past, helped to push the retailer's second half revenue up 3% to 拢390m.
The ad showed black-and-white scenes of famous London landmarks, including the London Eye and Big Ben, and pictures of Weisz with fellow British actor Ioan Gruffudd embracing and walking hand in hand.
Weisz was signed for the campaign after the Kate Moss scandal broke and the supermodel was dropped from promoting Burberry's fragrances.
Rose Marie Bravo, Burberry chief executive, said: "Retail operations were the highlight of Burberry's fourth quarter. Consumers' favourable response to spring merchandise, particularly womanswear, and an exciting advertising campaign contributed to the strong retail performance.
"At the same time, the strategically important shift to concession format for a significant portion of our business in Spain was completed.
Total revenue for the retailer rose by 3%, while wholesale sales decreased 7%, in line with expectations.
The retail sales rise is also said to be driven by newly opened stores worldwide.
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