The campaign features a Twitter-powered knitting machine nicknamed Knitbot that responds to the hashtag #jumpers4des.
The more hashtag mentions received, the more jumpers the Knitbot will make.
Jennifer Anton, Budweiser’s UK marketing manager, said: "We wanted to promote and celebrate the important role that designated drivers play in a fun and engaging way, with our own take on the festive knitwear trend.
"We believe this process of knitting by the power of tweets is the first of its kind, and the end result with our Knitbot machine is something quite spectacular."
The Twitter campaign runs from 10am today to 10am on 6 December.
Designated drivers and their friends will get the chance to win their own jumper, made by Knitbot, on the Budweiser UK Facebook page.
Budweiser will donate a percentage from the sale of its Give Back packs in Asda to the charity RoadSafe, the UK's leading forum for promoting and devising solutions for road safety problems.