The service, which is expected to launch in the autumn, will extend Sky Active's line-up of retail and travel services while providing a significant new distribution platform for Lastminute.
The deal will see Sky offering a variety of Lastminute services, including travel deals, theatre tickets and retail products, to viewers with up-to-the-minute availability and pricing.
Sky Active is available through digital satellite television in 5.5m homes across the UK and more than 7m Sky Digital viewers used interactive services in 2001.
Jon Florsheim, managing director of Sky Interactive, said: "BSkyB looks forward to welcoming one of Europe's best-known internet brands to the UK's leading interactive television service. Lastminute's high-quality range of travel and entertainment deals will be a valuable addition to the array of products on offer to Sky Active users."
Lastminute group managing director Martha Lane Fox added: "Using Sky Active as a transaction platform further builds on Lastminute.com's multichannel, multiplatform strategy and builds a strong partnership with BSkyB, the UK's market leader in digital commerce."
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