The episode, due to air in the US on April 13 on NBC, will see the 'Toxic' singer starring as a Christian conservative hired as a talkshow sidekick to Jack on his Out TV network.
Spears will be seen fronting an Easter cooking segment called 'Cruci-fixins'.
Right-wing religious pressure group, the American Family Association, criticised NBC for "mocking the crucifixion of Christ" and slammed the network for planning to airing the show a day before Good Friday saying it will "further denigrate Christianity."
"NBC does not treat Jews, Muslims or other religions with such disrespect. Yet the network demonstrates a deep hostility toward followers of Christ," the group said on its website.
The news comes a week after NBC's controversial miniseries 'The Book of Daniel', starring 'Legends of the Fall' actor Aidan Quinn, was axed.
NBC failed to find commercial sponsors for the show and several affiliates had refused to air it after protests from Christian groups over its content, which included alcoholism, bisexuality and a pill-popping priest, although NBC said it pulled the series after less than a month due to low ratings.
If you have an opinion on this or any other issue raised on Brand Republic, join the debate in the .