The new stadium is expected to finally open next month and attract 2.6m fans in its first year, while the Tube station is also the destination for the smaller music and sports venue Wembley Arena.
CBS Outdoor, formerly known as Viacom Outdoor, points out that the stadium has no sponsor and will feature multiple advertisers, making the Tube station a potentially doubly valuable media property.
The station has been refurbished and extended, and CBS Outdoor has installed its new LCD panels on-site. The package on offer also includes bespoke ticket hall and corridor sites, Bluetooth and branded seats within the station.
Justin Stark, head of impact at CBS Outdoor, said: "This is the first time we have ever offered a single brand a strategic advertising platform on this scale.
"It's an exceptional opportunity for the right brand to captivate an affluent, dynamic and diverse group of consumers who are in a positive and receptive mindset."
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