The monthly magazine is aimed at eight- to 12-year-old-girls and will feature fashion, celebrity interviews and photo stories.
The launch will be supported by an integrated marketing campaign including above-the-line TV and press advertising and a dedicated PR campaign.
BBC Worldwide is in the process of securing promotional spaces with key retail partners to ensure maximum exposure for the title.
In addition, Fremantle Licensing Worldwide has secured licencing deals with World of Calenders, which will produce a 2006 Mysti calender, and Event Merchandising, who will be developing an online shop via the .
Fremantle is also planning to develop a range of Mysti clothes and toiletries, with hair and beauty products being developed later down the line.
Dom Wheeler, vice-president licensing UK at FremantleMedia Licensing Worldwide, said: "We are confident that, working with great partners such as BBC Worldwide, World of Calenders and Event Merchandising, we can continue to provide the rapidly growing number of Mysti fans with desirable, interesting and funky products that every girl wants."
'The Mysti Show' first aired on BBC One and BBC Two in April 2004 and quickly rose to become the highest rated Saturday morning show among 10- to 15-year-old girls.
Last year, celebrity guests included Jackie Chan, Julie Andrews, Blue, McFly, The Cheeky Girls and Jennifer Ellison.
The second series is due to air later this year.
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