Sugar will be based in Ad2one's London office and will be overseen by Matt Gee, the former head of digital at advertising agency WCRS.
The new offering will launch with a team of nine, and aims to offer clients a "truly integrated multi-service digital package".
Grant Allaway, group director at Ad2one, said: "By providing creative together with digital ad sales, Ad2one is offering a true market first.
"Sugar is reflective of an evolving digital market. We are uniquely positioned to offer advertisers bespoke and innovative ways to reach their target audience."