Cano Lopez went on sick leave in December along with Dawn Orr, the UK data leader. Orr's departure was confirmed in mid-December but it has taken until now for Acxiom to reveal that Cano Lopez is also out.
David Allen, European CEO of Acxiom, said: "Jon wishes to pursue new interests and we thank him for his contribution and wish him all the best for the future."
Cano Lopez joined Acxiom in 2004 when it absorbed Claritas Europe and Consodata. He was formerly managing director of Claritas subsidiary Altwood Systems.
Last week, Acxiom shares fell around 8% in the wake of its third quarter results, which company leader Charles D Morgan called "disappointing".
Quarterly operating income was down 3% year-on-year to $51.3m and revenue was up 2% year-on-year to $352.8m.
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