Jason Kuperman (pictured), the former director of interactive at Tequila\ in Los Angeles, will run the Shanghai office.
Gavin Heron, the TBWA\China chief executive, said: "With Agency.com in China, we are able to deliver world leading interactive solutions to clients."
Meanwhile, the Agency.com Milan managing director, Franco Ricchiuti, will oversee both Italian shops.
During the past 12 months, Agency.com has also launched offices in Brussels and Dublin.