Ideasfactory has tied up with BoreMe.com, the world's largest collection of viral emails, and digital agency DS Emotion to push the campaign.
The winning agency will receive media exposure and free placement on BoreMe's homepage for two weeks. "The impact and reach of viral emails is phenomenal and we're going to make this an annual fixture," said C4 interactive comminsioning editor Adam Gee.
Entries can be submitted from Monday 17 October to 5 December at www.channel4.com/germ.