The 104-page perfect-bound magazine, Vanity Fair Travel, will be bagged with the April issue, out this Friday (10 March).
It is set to be one of several editorial-led supplements this year after just two in 2005 that covered watches and jewellery.
Tia Graham, Vanity Fair's associate publisher, said: "Our readers travel a lot and said they wanted us to cover travel in the same way we write features. It's a whole new audience for travel advertisers and it's very text-heavy, giving ads a greater standout."