Petrella was previously creative director for digital at Proximity London for two and a half years, where he was responsible for developing the creative direction and quality of the agency's digital output.
Prior to joining Proximity, Petrella spent over four and a half years working with Wheel Group, including roles as head of design and associate creative director.
During the course of his career Petrella has worked with brands including Marks & Spencer, Paul Smith, Lycos and the COI.
He said: "Twentysix has been involved with some really cutting edge and innovative creative projects in the past. I am really excited to be a part of the team and help the agency continue to break the creative mould."
Twentysix has also appointed Haydn Kerr as senior copywriter and Marcus Moret as senior project manager.
Kerr will work closely with Lex de Wynter, Twentysix's digital strategist, helping the agency develop a strategic direction for all client communications.
He joins from DraftFCB, where he spent a year as manager of the digital copywriting team.
During this time he worked across accounts including Saab, Oxfam, Cadillac, Nivea for Men, the Post Office, Stella Artois, Vauxhall, and Chevrolet.
Moret, who will run Twentysix's Epson account, has spent a decade in the digital industry working with brands including Sony, the Guardian, Vodafone, the BBC, Cadbury, MTV, Diageo, Nokia, the Royal Navy, Epson and Toyota.
He brings a wide range of online expertise, from strategy and account direction to project management and copy writing. He also has experience with web branding, design, usability, information architecture, content management, search marketing and web metrics.