The company, which as well as publishing the Daily Mirror is the UK's largest regional newspaper group, says it is streamlining its newspaper business in an effort to "maximise growth and address current trading conditions".
The cuts represent around 2% of the group's UK workforce.
In a statement, the company said, "The current cost saving initiatives should mitigate part of the profit shortfall arising from the difficult advertising market."
Trinity Mirror also publishes the Sunday Mirror, the Racing Post, and the Daily Record and Sunday Mail in Scotland.