Ken Hom has sponsored the daytime chat show, hosted by Des O'Connor and Melanie Sykes, since it returned to ITV's daily schedule last September.
The show won the Royal Television Society Award for best daytime programme last March.
James Villa Holidays, the independent tour operator, will use the sponsorship to supplement its DRTV work. The £450,000 deal, negotiated by ARM Direct with Carlton, includes eight break bumpers during each show.
James Villa Holidays managing director Darren Needham said it had identified a close fit between its upmarket villa holidays and the Des and Mel audience.
He added that he expects the sponsorship to significantly raise awareness.