The screen is the first of 15 the company is aiming to roll out in London and Manchester this year.
The first LED screen, located in Kensington, London, is the latest in a series of digital developments for the company. It is also trialling digital six-sheets at Birmingham's Bullring shopping centre and London's Victoria Station.
The digital 48-sheet screens allow campaigns to be updated instantly, with Titan envisaging improved levels of creativity as a result, as well as providing an economically sound and environmentally friendly delivery system.
Meanwhile, Titan has taken over the ad management for the Trafford Centre's food-hall screen, set to be replaced in the coming months.
Titan also owns the advertising rights to Transvision, the Sky News and information product installed at major rail stations.