The campaign kicks off this week on Clear Channel outdoor sites on London's Cromwell Road and runs until October 14.
The campaign was planned and created by Cheil UK and booked by Rapport to "ensure maximum impact and exposure" for the new Galaxy Note 10.1.
The campaign showcases a large 3D cut-out of the tablet, supported by 2m-high 3D hands, in an effort to bring the product to life across 96-sheet billboards.
Neil Chapman, head of creative at Clear Channel UK, said: "The scale of this campaign really utilises the space and impact afforded by our Cromwell Road site, making it the perfect fit to help launch the new Samsung Note.
"We have some of the largest 3D models we’ve ever built highlighting the unique features of the Galaxy Note, so it’s going to be impossible to miss!"
Clear Channel's Cromwell Road site spans 75 metres of a busy London A-road.
The campaign follows the recent announcement that Clear Channel is partnering the moustache-growing charity event, Movember, to raise awareness and funds for men's health issues such as prostate and testicular cancer.