The agency's NSPCC "cartoon" won the Worldwinner Television award, the Grand Prix in cinema, three golds including UK National Award, Best Sound Design and Public Services. The agency also won three bronzes for Toyota and monster.com.
The event, also saw Lowe scoop the television Grand Prix for Reebok "sofa", which also won gold in the retail category and a gold in cinema. Stella Artois' "doctor" won gold for best direction, with the HSBC ad "retirement" gaining a silver.
The radio Grand Prix went to DDB Chicago for its long-running Bud Light campaign.
Abbott Mead Vickers BBDO was another high-scoring UK agency, with a joint gold in post-production for its road safety campaign. It shared the award with Bartle Bogle Hegarty for Levi's "odyssey". AMV also won Best Editing for BBC "rush hour" and two silvers and a bronze.
TBWA/London won a gold for Best Writing for its John Smith's campaign and a gold for the PlayStation 2 "bambi" spot. John Smith's also won a silver and bronze award.
Gorgeous won the Palme D'Or for best production company.
This year's festival attracted a record 930 entries from 20 countries.
Attendees were up slightly on last year, according to the festival director, John Holohan, with about 265 delegates from 20 countries.
Holohan said plans to move the venue to attract more delegates have been dropped in favour of targeted workshops.
The jury was chaired by Matthew Bull of Lowe Bull South Africa, with other members including Peter McHugh of 180 Amsterdam and Shay Madden from McCann-Erickson Dublin.