Using the strapline "Stand up, speak up", the ad has been created by Wieden & Kennedy Amsterdam and is backed by Nike. Several executions have been developed, all of which star the Arsenal and French international player Henry, along with Barcelona star Ronaldinho.
The English version also features Manchester United stars Ferdinand and Ruud Van Nistelrooy, while Real Madrid's Roberto Carlos lines up for the Spanish version alongside Barcelona's Carlos Puyol.
The campaign is part of a new fundraising scheme to encourage fans to wear interlocked black-and-white wristbands as a symbol of their stand against racism, which can be bought for €2, or £1.50 in the UK.
The bands will also be worn by players across Europe from the end of January, and money raised by their sale will go to the Stand Up Speak Up fund, to conduct research into racism in football, and distribute money to organisations in Europe that are working on the problem.
The campaign comes after Henry was racially insulted by Spanish coach Luis Aragones, who called him a "shitty black man". Henry said he would "forgive but never forget". English players, including Ashley Cole, also faced racist monkey taunts when they played Spain in November. The Spanish Football Federation was fined just £45,000 by Fifa for the behaviour of fans.
The advertisement is completely silent until the endline, with the players holding up signs to get their message across, telling fans "We need your voices to drown out the racists wherever you hear them". At the end of the English spot, Van Nistelrooy says "stand up", while Henry delivers the line "speak up".
The television campaign was written by Mark Hunter and art directed by Anders Stake, while an accompanying print campaign was written by Antony Goldstein and art directed by Ollie Watson.
Henry said: "Racism is one of the biggest problems facing football across Europe. People may think the problem has disappeared, but it hasn't. The players on the pitch need the help of all fans to help drown out the racists and tell them their actions aren't acceptable."
The campaign breaks in the UK on February 1, and in France, Germany, Spain, the Netherlands and Italy on February 5.
The other stars in the ads are: Claude Makalele and Phillippe Mexes, in the French version; Christoph Metzelder and Otto Addo, in the German version; and Adriano and Fabio Cannavaro, in the Italian ad.
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