It will run idents every Sunday and Monday for 10 weeks from 29 March on TV and on-demand.
The idents were developed by 5Creative and show a man in a chair, acting as a magician. Each time he points towards a man or woman on a stage they are shown in different job roles. The last change is a mouse to a "llamacorn".
Mark Rhodes, the director of marketing at Reed.co.uk, said: "This deal was a logical next step in further building awareness of Reed.co.uk as the UK's number one job site and widening the reach of our highly successful 2015 TV campaign.
"Channel 5's growing audience represents an appealing target for UK employers and the ident platform is a great setting for us to promote a positive message to UK workers – banish the Sunday night fear and start loving Mondays."
The idents were created and produced by Mike Sumpter. The deal was struck by Media Odyssey.
Agostino Di Falco, the deputy commercial sales director at Channel 5, said: "Reed.co.uk are experts at helping people find jobs they love and the messaging of the Love Monday’s campaign is a great fit for our audience, reaching them across multiple channels and, via VoD, whatever the device they’re using."