The ads, which break this week, will aim to show how technology helps consumers indulge their passions.
The multimillion-pound integrated drive, created by M&C Saatchi, represents the technology chain's biggest single marketing investment.
It will introduce the strapline 'Whatever your world, PC World', and will cover the retailer's full range of products.
'In the current challenging economic environment, it would be easy for us just to run "deal" campaigns, but this new strategy is a sign of our confidence,' said Niall O'Keefe, marketing director at PC World.
A 60-second ad, which launches tonight (Wednesday), will take the viewer from a childhood cinema experience to adult life and will feature actor Christian Slater.
A second 40-second spot, which uses deceased musician Jimi Hendrix, will launch on 1 June. This execution also shows how a grandmother uses gadgets to stay in touch with her family in Australia.
The ads will appear during the final of Britain's Got Talent and the launch of this year's Big Brother series.
Radio spots include voice-overs by comedians Norman Lovett, who played Holly the computer in Red Dwarf, and Matt King, best-known for playing the character Super Hans in Channel 4's Peep Show.
Press ads will share the brand-led approach and focus on people's interests, including photography and gaming.
The campaign follows an 18-month programme in which 7000 PC World staff were retrained to offer customers better advice. The chain has also invested in redesigning its stores and brand identity.
According to O'Keefe, PC World will also continue with some price-focused ads. These will run during peak retail periods, but will have a similar look to the main campaign.
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