Parkinson, who had been at the children's network, run by MTV Networks and BSkyB, for more than three-and-a-half years, will leave at the end of September.
During her time at Nickelodeon, she has overseen the launch of Nick Toons, as well as running Nick Replay and Nick Jr. Previously, she was vice-president of marketing at Turner Broadcasting Systems Europe until 2001.
In her new role, Parkinson will oversee the management and development of Disney-branded channels and blocks across the region, including 10 Disney channels, six Playhouse Disney Networks and 23 Disney-branded slots.
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