The centrepiece of the campaign, which was created by Common Sense Media, features Sutherland urging parents to closely monitor their children's internet usage.
Common Sense Media is providing a dedicated , where parents can access a downloadable guide to safe internet usage and safety tip cards aimed at teenagers.
The campaign will also feature ads to be broadcast on News Corp's Fox, which produces '24', and other News Corp-owned cable network channels, including National Geographic and Fox Movie Channel, as well as banner ads on the Fox Interactive Media-owned websites AmericanIdol.com, Rotten Tomatoes and AskMen.com.
MySpace has come under fire from parents in the US, where the FBI is currently investigating more than 500 claims of sexual assault that allegedly occurred after children met adults through MySpace.
Hemanshu Nigam, chief security officer at MySpace, said: "Kiefer Sutherland carries our internet safety message to families in a compelling way, and the more informed parents are, the safer families will be online."
A recent poll conducted by Common Sense Media found that 85% of parents considered the internet to be the riskiest form of media available to children, although 77% accepted that it was an important educational tool.
James P Steyer, chief executive officer at Common Sense Media, added: "In order to protect children from running into trouble on the internet, parents need to know where their kids live online and need simple, practical information to help them keep their kids safe."
MySpace, which was bought by Rupert Murdoch's News Corp for $580m last year, said it has been working on enhancing its safety features, as well as a number of ad campaigns to be used in conjunction with the US-based National Center for Missing and Exploited Children and the American Advertising Council.
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