MPGI walked away with the multi-market business after successfully pitching against Publicis Groupe's ZenithOptimedia, Omnicom's OMD and incumbent UM.
Sold in nearly 150 countries worldwide, the iconic British brand made a profit of £111m in its last reported financial year.
MPG International will handle all on and offline media activity from its London office, with local agencies implementing strategy and taking care of media buying.
According to The Nielsen Company, Clarks spent £6.1m on media in the UK in 2008, including £4m on TV and £2m on press.
Louise Deane, procurement category manager at Clarks, praised MPG's "leading digital expertise" and said the appointment comes ahead of "a year of expansion and development" for the company.
Started in 1825, by brothers Cyrus and James Clark, the company remains 81% family owned, with the rest held by employees and other institutions.
Clarks joins a number of blue chip corporate clients on MPG International's roster, including two looking to consolidate their global business, Reckitt Benckiser and Danone, which sit alongside CNBC and Credit Suisse.
Marc Mendoza, chief executive of MPG, said he was looking forward to working with Clarks "to grow and transform the business".
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