The ad, which breaks tonight, goes inside the mind of a cannabis user, Simon, who is holding a party.
Clones of Simon begin arriving, each displaying a different side effect of taking the drug such as giggles, panic attacks and munchies.
A voiceover which explains: "the more you mess with cannabis, the more it can mess with your mind", ends the spot, along with text explaining that cannabis has been reclassified as a class B drug.
A website, www.talktofrank.com/cannabis, created by Profero, supports the TV campaign. The microsite invites users into a party where they are encouraged to have a drag on a spliff so that they can experience how cannabis can mess with your mind.