Nolle, the former head of retail advertising at News Group, will head sales for the new division, which is Mirror Group's third ad sales unit.
He will recruit a team of three people to build direct relationships with new and existing advertisers.
Mirror Group's existing innovations and advocacy strategic sales teams, headed by Keith Yonish and Gavin Gordon, which develop creative sponsorship deals and agency relationships, will remain in place.
Mark Field, head of business development, said: "What we have been looking at over the past 18 months is how to develop our advertising business and where we need to spend more time and improve our skills base, and that has led to the development of a specialist client sales team."
Field said the creation of the team would help Mirror Group Advertising to spend more time with clients, but promised the move was not aimed at cutting agencies out of the loop.
He said: "There is pressure being put on the agencies all the time, but we want to do this with their blessing and make client sales a part of our relationship with them."
Field also revealed that the Daily Mirror is about to launch a significant cross-media campaign for food-labelling organisation GDA, planned by agency OMD.