It will launch the portal, formed by a partnership between Microsoft and start-up firm What On Earth Is Going On - a company founded by David Alberts, the former creative director of ad agency Grey London - in the next few months.
The service will act as a forum for debate on certain issues including related editorial content from users and the brands themselves.
Gayle Troberman, senior director of MSN's branded entertainment and experiences team, said: "Consumers come to us for a massive array of services and everyone is passionate about a different set of causes.
"We're inviting brands to be a catalyst and to start a conversation."
Troberman admitted, however, that some brands are not bold enough to position themselves next to such user-generated content.
Alberts said that MSN may choose themes to cover every month while also encouraging users to contribute their own content.
The move follows Microsoft's sponsorship of green issue event Live Earth, which was watched by more than eight million people online.
According to MSN, the new website will offer brands the chance to get their message across through bespoke advertising opportunities.
MSN attracts 528 million unique users a month globally and hopes to tailor its latest sites to issues relevant to local markets.
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