Its world news broadcasts will air daily between 9pm and 1am. The launch will double the channel's reach in the UK, adding 9m homes.
CNN will broadcast a one-hour launch special on Thursday looking at the challenges in the Middle East.
CNN will offer live coverage of the 20 January inauguration of US President-elect Barack Obama, including the inauguration parade. From 27 January, it will offer coverage of the World Economic Forum in Davos, Switzerland.
The channel currently broadcasts more than 50 hours a week from its European headquarters in London.