Created by Leo Burnett, the ad breaks on July 1 and conveys the message that the only thing added to its burgers is a pinch of salt and pepper.
The commercial is an extension of last year's 'Planting' campaign, which featured families planting flowers that bloomed into a cow, a chicken and a sack of potatoes.
The latest TV ad in its 'That's What Makes McDonald's' campaign sees a group of families sent on a treasure hunt to find as many nought shapes as they can -- a nought-shaped bale of hay, a nought-shaped plant pot or a nought-shaped tractor wheel.
The voiceover says: "Nothing. Zero. That's what's added to our burgers.
"They're simply 100% beef from British and Irish farms, seasoned with a touch of salt and pepper. That's what makes McDonald's."
The TV work includes 60, 40 and 20-second executions that will run for an initial six weeks.
Other media will support the TV campaign, including print executions using the nought imagery while in-store branding will also reinforce the campaign message.
Jill McDonald, McDonald's chief marketing officer for the UK and Northern Europe, said: "Several years ago we realised that some of our best kept secrets are the ingredients we use to make our food.
McDonald's said that it has spent the last decade improving the quality of its main ingredients -- it now only uses free range eggs, British organic milk and chicken breast in its products.
McDonald said: "The 'That's What Makes McDonald's' campaign focuses on the ingredients at the heart of most of the meals we serve -- beef, chicken and potatoes.
"This is proving to be a hugely successful campaign that is, without doubt, contributing to the great sales momentum that we have in our business."