Television and radio activity developed by Leo Burnett will use the strapline 'Every step counts' to reinforce the idea that even simple forms of exercise - such as climbing stairs and walking - contribute to keeping fit.
It will be supported by magazine advertorials and trayliners in restaurants.
Campbell and Davies will feature in promotional material offering hints and tips on keeping active.
The campaign will support the launch of a healthy meal option called Go Active!, which will be available throughout August to back McDonald's Olympic sponsorship. Promotional activity has been created by The Marketing Store, with media planning and buying by OMD.
The campaign is part of a wider global initiative called 'Healthy Active Lifestyle', which will promote balanced diets and exercise. Last month McDonald's answered government calls for the food industry to advertise responsibly by creating a £1m educational campaign for children featuring brand icon Ronald McDonald (Marketing, 23 June).
Last week McDonald's UK chairman and chief executive Andrew Taylor quit after 25 years at the company. Peter Beresford, executive vice-president for McDonald's Japan, will replace him.