The 17-day event - a highlight of the city's cultural events calendar - will take place from 2 -19 July, and will also include appearances from artists including Rufus Wainwright, De La Soul and Lou Reed.
"We are very pleased to be able to bring together such a range of artists for the 09 event," said festival director Alex Poots. "Manchester has long thrived on invention, innovation and radical thought, and MIF aspires to be part of that tradition."
The biennial festival was launched in 2007 and introduced 25 world premieres including Monkey: Journey to the West - the opera composed by Damon Albarn - and Il Tempo del Postino - a group show by 15 of the world's leading contemporary artists.
Sir Richard Leese, leader of Manchester City Council said: "This year's programme is incredibly exciting and is even more ambitious than in 2007. To be hosting this internationally renowned festival of original new work is great for the city and further enhances its reputation as a leading international centre for art and culture in all its forms.
"It provides tremendous opportunities to showcase not only the city's artistic venues but also our home-grown talent alongside outstanding international artists, presenting work that is both innovative and ground-breaking demonstrating just what Manchester is about."
The 2007 event attracted more than 200,000 visitors to the city and had an estimated economic impact of £28.8m.
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