The company reported a second-quarter net loss, excluding amortisation of goodwill, of £10.6m, compared with £11m a year ago. Turnover was £27.8m, compared with £5.8m for the same period a year earlier, and gross margin rose to 13.9% from 9%.
Its UK and French operations will reach profitability within the next year, Lastminute's chairman Allan Leighton said, but a cost-reduction programme would mean about 50 jobs will be axed, mainly in overseas offices.
The firm bought French rival Degriftour last August and in February announced a deal to sell last-minute holidays on Thomas Cook's website.
Subscribers doubled to more than 3m in the past year and the number of customers actually buying products also more than doubled, the company claimed.
Shares opened at 62p on the London Stock Exchange this morning, up from Friday's close of 60.5p.