Karmarama, which bills itself as a "communications design agency", has been briefed by the human rights organisation to create a campaign as part of a "stop violence against women" drive.
The advertising will attempt to position domestic violence as a major human rights issue by targeting young men who are marginalised by traditional communications.
David Buonaguidi, Karmarama's co-founder and creative partner, said: "It is a real honour to be working with Amnesty, an organisation we support and admire.
"We have not simply offered it an advertising-led solution but will be working in a variety of media to drive our message home."
Kitcatt Nohr Alexander Shaw created Amnesty's most recent TV work, which featured the music of U2, a voiceover by Jeremy Irons and marked the pressure group's return to TV after a nine-year absence. Amnesty had previously been banned from promoting itself by the Radio Authority.
Karmarama's work is expected to break in the autumn and will run for two years.
Stephen Bowen, the campaigns director at Amnesty, said: "Karmarama's ideas are outstanding and we are really looking forward to working with them on this vital social campaign."