As part of the six-figure deal The Independent will promote Vodafone's "Passport" roaming service, which allows customers to use their home tariff abroad after a set-up fee of 75p.
Independent travel editor Simon Calder will be hosting the podcasts, which will be downloadable from The Independent's and Vodafone's websites beginning 20 May.
The podcasts will be part of a multimedia campaign across The Independent's print and online products. Tim Yates, Vodafone UK's chief marketing officer, said: "People will be able to access invaluable information on four top European holiday destinations in a number of ways. They can read about the cities in the paper, download podcasts or go to Vodafone Live! on their handsets."
Ben Reilly, business manager on Vodafone's account at OMD, added: "Vodafone is always looking at new ways to communicate the strength of its roaming offering to its consumers, and this cross-media deal allows it to provide excellent travel content across a variety of platforms."