The firm has simplified the range around four lines: Women, Men Classic, Active and Xtreme. Redesigned packaging will roll out this month to highlight the new brand structure.
TV and outdoor ads, created by DDB Dusseldorf, will break on 1 July, promoting the deodorants' effectiveness by focusing on the different personas a man takes on during a 24-hour period.
A website, created by Piranha Kid, and print activity in women's press will support the 24-hour theme.
Next year, Henkel plans to run ad activity teaching consumers the difference between anti-perspirants and body sprays. The work will target the teen to early-20s male market, and is likely to pit the brand against Lynx.
Henkel acquired Right Guard from Procter & Gamble for $275m last May, putting it behind only Unilever in the UK deodorant market.