Although Associated News refused to comment on the nature of Orlov's departure, industry sources believe it was part of the changes being implemented by the Evening Standard's new managing director, Mike Anderson.
Anderson took over responsibility for the paper last month, replacing Sally de la Bedoyere, who left Associated News after 17 years with the company. Anderson, who was previously the head of the company's morning freesheet Metro, was promoted as the Standard tried to get to grips with falling ad revenues.
Brydon and Anderson both share a background at the former CIA Medianetwork. Anderson used to be the new-business director of the agency while Brydon was the managing director until 2000.
Before CIA, Brydon spent 16 years at Abbott Mead Vickers BBDO, eventually rising to the position of media director. He began his career at Saatchi & Saatchi in 1979 and has most recently worked for the venture capitalist company Apax Partners.
Anderson's promotion from Metro's managing director to head of the Evening Standard is believed to be the first step toward a merger of the two titles' sales divisions.
Earlier this year, Veronica Wadley took over from Max Hastings as the editor of the Evening Standard. There then followed a succession of editorial departures.