The work, by WWAV Rapp Collins Scotland, begins later this month. It comprises two elements, one targeting a younger audience and the other the brand's traditional older market.
The first wave is designed to prompt younger, infrequent drinkers of Drambuie to try the drink over ice. A money-off voucher will be included to increase summer sales.
The second wave targets higher-volume consumers, encouraging them to share Drambuie with friends and try it as the base for a variety of on-ice summer drinks.
Drambuie is traditionally perceived as a winter drink - its strongest sales period is over Christmas.
The latest initiative follows a successful trial last year, when Drambuie launched a tester direct mailshot containing a branded ice tray.
Earlier this year the brand, which is owned by independent firm the Drambuie Liqueur Company, re-vamped its global identity to create a more contemporary feel.
Last May, it launched a Drambuie Cream extension to appeal to a younger generation, and in the run-up to last Christmas, it advertised on national TV for the first time in ten years. The campaign, through Burkitt DDB, also attempted to attract younger consumers.