The TV ad, created by Grey, will air from 21 February and is part of a £6m investment in the brand this year, according to maker Dairy Crest.
Further strands of the campaign include press ads, point-of-sale activity, promotions and digital media marketing.
The press campaign, which will feature coupons, is focusing particularly on Clover Lighter, as Dairy Crest believe customers are still fighting the flab after Christmas.
Nathan King, Dairy Crest head of marketing for butter and spreads, said: "This campaign builds on Clover’s recent success and we have exciting plans for further support during 2011. We look forward to further growth as a result of this investment."
Dairy Crest's other brands include Cathedral City cheese, Country Life, Utterly Butterly and Frijj shakes.
Media buying was carried out by Universal McCann.