The £4m push, by Euro RSCG, is based around the creative concept ‘London is our lounge'.
Print, outdoor and digital executions will show consumers waiting to board flights at famous London landmarks, such as Regents Park.
The campaign breaks on Monday 7 September, and will be backed with live CityJet departure information being displayed on the Reuters News ticker at Canary Wharf.
‘In effect we need to raise awareness of two brands - CityJet and London City Airport,' said Patrick Edmond, general manager commercial at CityJet.
‘The creative shows a direct comparison with travel and check-in times to Heathrow to clearly show the benefits of flying with us from City Airport.'
Euro RSCG was appointed to CityJet's pan-European ad account in March, following a final pitch against Grey London.
Air France KLM-owned CityJet recently merged with Belgian carrier VLM Airlines, and now occupies 50% of the landing slot at London City Airport.