The ads, which were created in the style of Ishihara eye tests by CHI & Partners, are designed to convey the impact that full colour will have on the paper's "reading experience".
Each ad features an image of a celebrity made up from coloured spots, similar to the Ishihara test, which is used by opticians to test if a patient is colour blind.
The ad featuring Winehouse, says: "Are your eyes ready for more colourful arts and entertainment?"
Meanwhile, an ad featuring George Bush asks: "Are your eyes ready for more colourful news?"
The Times has invested £650m in new colour printing presses under the stewardship of new editor James Harding.
CHI won the £15m ad account for The Times in October last year, which ended the paper's 12-year relationship with Rainey Kelly Campbell Roalfe/Y&R.
CHI previously held the £8m ad account for The Telegraph Group but resigned it to work with The Times.