For two years CBS Outdoor has donated poster space at King's Cross Underground station to the charity to create awareness of its fundraising. The adverts featured pictures of a sufferer, John, from his days as an active footballer and later through the different stages of his disease.
The last poster, poignantly showing his empty bed, was in place this week to mark the beginning of MND Awareness Week.
It is hoped the campaign will raise awareness of the association's work and so go someway towards finding out the cause of Motor Neurone Disease.
Peter Charlton, national sales director at CBS Outdoor, explained how the campaign had helped build a connection and develop a relationship with tube passengers who have witnessed John's journey.
"The powerful message with dramatically changing copy over time is a clever and extremely arresting way to create a message with real meaning to raise awareness of MND," he said.