Executives at the paper, which is owned by the Barclay brothers, are reported to have been in talks with USA Today owner Gannett, Chicago Tribune and LA Times parent Tribune, Hearst and the Washington Post Company.
However, before US expansion takes place it is expected there will be a push in Europe and talks are also reported to be going on in Dublin and Paris.
The expansion talks, which are being headed by the paper's publisher Andrew Neil, follow the beefing up of the paper's international sales operation with the appointment of Susan Relihan, a former sales manager at the National Magazine Company and US Vogue, as international sales manager.
Relihan will coordinate advertising sales between its European sales operations in France, Germany and Switzerland and will report to the former Financial Times global ad director David Walsh, who is another recent senior hire at The Business.
The US talks follow an agreement in the UK that will see The Business distributed for free with The Mail on Sunday and with Scotland on Sunday north of the border.
Starting from autumn, the newspaper will be distributed in upmarket parts of London and 100,000 copies will be given away with Scotland on Sunday, which is also owned by the Barclay brothers.
Neil has said his ambition is to turn The Business into a paper with a circulation of between 400,000 and 500,000 through global partnerships.
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