The changes, instigated by Radio 1 controller Andy Parfitt, are set to be announced later this week and it is thought that at least three of the current night-time presenters will go.
As well as those already mentioned other late night session DJs include Tim Westwood, Judge Jules, Steve Lamacq, Fabio & Grooverider, Seb Fontaine, Trevor Nelson and Gilles Peterson.
BBC veteran Peel is thought to be safe as is recent hire Lowe, who has had his station hours doubled to 12 a week. Lowe who is also an MTV2 presenter, moved across from alternative music station Xfm earlier this year and his ability to embrace a broad range of musical tastes from rock to hip-hop is seen in his credit.
According to reports, Parfitt said that there were no plans for a more mainstream feel and that the station was still committed to delivering cutting edge music, but he told The Independent, "we can't just preach to the converted".
Plans are underway to try to broadcast more music popular with the station's key 15-24 year old target audience and encourage new talent.
Radio 1 recently restructured its daytime schedule, dropping presenters including Mark Goodier and Mark & Lard. Sara Cox was also moved from breakfast to make way for Chris Moyles, who delivered an extra 400,000 listeners in the latest set of Rajar figures.
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