The publisher is believed to be reluctantly cutting back on its Metro Life sections, which cover the regionalised arts, entertainment and food pages.
No commercial jobs are expected to be directly affected.
A spokesman for Metro said: "Metro today announced a series of potential redundancies from its regional editorial operations. The redundancies are part of Metro's cost reduction plans, in response to the challenging economic conditions we face.
"We will be consulting fully with employees affected by this announcement."
The weekday morning newspaper is currently distributed in 16 British cities and in the last year has attracted a record readership of more than 3.5 million, according to figures from the National Readership Survey.
The anticipated redundancies follow Associated Newspapers reporting a 15% drop in ad revenue in the first half of 2009, to £184m. Other newspapers in the group include the Daily Mail, The Mail on Sunday and the Irish Mail on Sunday.
Metro was launched in March 1999 as a free newspaper targeting urban commuters.
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