The group, which collates information on illegal online content, such as images of child abuse, before passing it to the police, has appointed Iris to handle the campaign.
The work will include PR as well as outdoor and online advertising. The ads, which focus on the organisation's 10th anniversary, will break on 24 October.
IWF will also run a series of events in major cities across the UK, intended to educate police, teachers and child-protection workers about its work.